Keyboard and mouse not working after booting Windows - posted in Windows 10 Support: Keyboard and mouse works in bios and also in the UEFI Windows recovery blue screen, but not when Windows is booted.If the USB peripherals are the culprit of the “no boot device” issue in Acer computer, try to replug them one by one until you find out the exact one that makes your. So, you can try to disconnect all your USB peripherals from your computer, including the USB keyboard and mouse because some users report they can also trigger this problem.